As such, development of STESK strategies have the potential to improve the efficacy of current “shock and kill” strategies. Finding novel therapeutic strategies that can Shock latent HIV, enhance Translation of viral transcripts, enhance immune Effector functions, and Sensitize reactivated cells to apoptosis could enhance Killing and elimination of latent HIV reservoirs.
Pharmacological enhancement of IL‐15 signaling to improve “shock‐and‐kill” strategies against latent HIVġGeorge Washington University, Microbiology, Immunology, and Tropical Medicine, Washington DC, United Statesīackground: Despite effective anti‐retroviral therapy (ART), the largest barrier to HIV cure remains the formation of a latent reservoir early after initial infection that cannot be cleared by subsequent ART treatment.
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